Opioid overdose is a life threatening condition created by excessive opioid levels within a person’s circulatory system. Examples of opioids are: morphine, heroin, fentanyl, tramadol, oxycodone, and methadone. Opioids, because of their effect on the part of the brain that regulates breathing, may cause a person to develop ineffective breathing or cause complete respiratory arrest and death. The signs and symptoms of an opiate overdose often include: a decreased level of consciousness for the person; the person’s eyes exhibiting pinpoint sized pupils; and respiratory depression. Other symptoms can include seizures and muscle spasms.